While running "systemctl --system daemon-reload", we see calls like "systemctl start nginx.service" fail. Once the reload is complete, services can be manipulated again. This is particularly visible on systems with large numbers of units because systemd takes longer to reload. The expected effect of a daemon-reload would be having "systemctl start nginx.service" block until the daemon is reloaded and has processed the "start" request.
I don't think this is an issue anymore. I certainly haven't seen it in a long time.
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