Some clients (gnome-boxes, spicy), that are using "resize-guest" property enabled, are not resizing the display of a Windows guest when the VM has 2 and more QXL devices.
Fixed by http://lists.freedesktop.org/archives/spice-devel/2015-June/020453.html spice-gtk commit 5be627986bf00436b8fd48f365fca47dd87b4754
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